Nexium and sleep disorder

Introduction to Nexium

Nexium, commonly known by its brand name, Nexilis, is a medication widely used to treat various gastrointestinal conditions. Its development was driven by several objectives: 1. To develop a novel approach to the treatment of gastroesophageal reflux disease (GERD), 2. To develop a novel formulation of esomeprazole, 3. To develop esomeprazole for long-term use in patients with erosive esophagitis and erosive heart failure.

Current Market Scenario

The Nexium market is projected to grow from USD 2.1 billion in 2023 to USD 4.2 billion by 2034, reaching USD 6.4 billion by 2034 according to CAGR data. The growth trajectory for the Nexium sector includes growth from generic, branded and injectable formulations, segmented payers, emerging market segments, and specialty and specialty applications.

Market Size and Growth Projections

  • The global Nexium market was valued at USD 6.4 billion in 2023 and is expected to reach USD 6.8 billion by 2034, growing at a Compound Annual Growth Rate (CAGR) of 6.2% from 2024 to 2034[1].
  • The market is segmented into esomeprazole (Nexium 24 HR), omeprazole (Nexium 24 HR Oryzanide), proton pump inhibitor (Nexium 3D Inhibitor), and proton pump inhibitor (Nexium 4-AT). The global esomeprazole market is expected to grow at a CAGR of 2.5% from 2024 to 2034[1].

Regional Analysis

The Nexium market is segmented into North America (United States, Canada, Australia and New Zealand), Europe (Finland, Germany, France, Italy, New Zealand, Spain and trailblazer countries), Asia Pacific (Australia, India and South Korea), and Latin America (Mexico, Brazil, and United Kingdom).

Key Drivers of Nexium Market Growth

  • Increasing prevalence of gastroesophageal reflux disease (GERD) and the rise in non-alcoholic steatohepatitis (NASH) are key drivers of the demand for Nexium[1].
  • The expansion of healthcare infrastructure and the increasing number of medical facilities are additional significant drivers[1][2].

Regional Insights

North America, Europe, and the Asia Pacific are notable regions for the global Nexium market. North America is expected to grow at the fastest CAGR during the forecast period. The Asia Pacific region, which includes India and South Korea, is anticipated to witness the fastest growth rate during the forecast period. The Latin America region, which includes Mexico and the United Kingdom, will grow at the fastest CAGR during the forecast period[2][3].

Market Drivers

  • The prevalence of GERD and the rise of non-alcoholic steatohepatitis (NASH) are key drivers of the global demand for Nexium[1].
  • The healthcare infrastructure and the increasing number of medical facilities are also key drivers[1][2].

Regulatory Landscape

The Nexium market is regulated by the Federal Drug and Food Safety Authority (FDA and FDA) and the European Medicines Agency (EMA). The Nexium patent held by Nexium manufacturer Pfizer in the United Kingdom (under the brand Esomeprazole) and the U. K. (under its brand Omeprazole) is valid until 2028. This regulatory requirement means that manufacturers can offer their products without requiring prior authorization from the FDA and/or EU member states[1].

Competitive Landscape

The Nexium market is competitive, with several major players operating in the same market. The competitive landscape includes several key players in the following areas:

  • Generic and Brand Formulation: The global Esomeprazole market is segmented into esomeprazole esomeprazole (Nexium 24 HR) and omeprazole omeprazole (Nexium 24 HR Oryzanide).
  • Insider Pricing and Discounts: Insights by Region, which is expected to drive the market growth during the forecast period[1].

Gluten Free and Nexium for Heartburn

Heartburn is an acid-related condition that can occur on all sides of the throat, and can also affect the back of your throat. This condition can lead to a variety of symptoms, including heartburn, but it’s important to note that these symptoms are not limited to the back of your throat. If you suffer from heartburn, talk to your healthcare provider first. They can discuss the potential risks and benefits of using certain foods or medications, including NEXIUM® (esomeprazole magnesium)

What is NEXIUM®?

NEXIUM® is a brand-name prescription medication that contains the active ingredient esomeprazole magnesium. It’s commonly used to treat conditions like gastroesophageal reflux disease, heartburn and acid reflux. NEXIUM® works by blocking the production of acid in the stomach, allowing the acid to be passed through the esophagus, stomach and small intestine to reach the site of the burning sensation. This helps to relieve symptoms such as heartburn, acid reflux and discomfort.

Is Nexium® gluten free?

Nexium® is available as a brand-name prescription medication that contains the active ingredient esomeprazole magnesium. It is commonly used to treat conditions like gastroesophageal reflux disease (GERD), heartburn and acid reflux. However, NEXIUM® is also available as a generic medication that contains the same active ingredient as the brand-name medication.

Is Nexium® the same as Nexium®?

Yes, Nexium® is the brand name for esomeprazole magnesium. However, the inactive ingredients in Nexium® are the same as in Nexium®. NEXIUM® is a brand-name medication and should only be used under the supervision of a healthcare provider. They will determine the appropriate dosage and ensure that the medication is not causing a harmful effect to the health of the individual taking it.

How should I take Nexium®?

Take this medication exactly as prescribed by your healthcare provider. The typical starting dose is one capsule taken before eating a small meal and at least 4 hours before bedtime. The dosage may vary depending on the condition being treated and the severity of the symptoms. It’s important to follow the recommended dosage and not exceed the prescribed amount. If you have any questions or concerns, be sure to contact your healthcare provider for guidance.

How long does Nexium® take to work?

NEXIUM® is usually taken once a day. It’s important to take the medication as directed by your healthcare provider to be effective and to stay on track with your treatment schedule. If symptoms persist or become more frequent, please seek medical attention immediately.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it’s close to the time of the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

What should I do in case of a missed dose?

If you accidentally take too much of Nexium®, please contact your healthcare provider or pharmacist. They will be able to give you a full prescription for the medication, even if you feel better. It’s important to contact your healthcare provider right away if you experience any unexpected side effects.

What should I do in case of a overdose?

If you suspect an overdose, please seek medical attention immediately. Symptoms of an overdose may include nausea, vomiting, stomach pain, or bloody diarrhea. If you suspect you have taken too much medication, seek medical attention immediately. If you suspect you’re having a stomach ulcer, contact your doctor. They may prescribe a different medication, or they may adjust your dose.

Nexium® 24HR 20mg Mini Capsules provide lasting relief from frequent heartburn and acid reflux in a 53% smaller capsule (based on volume of the capsule vs Nexium® 24HR Once Daily Dosing Tablet)

Nexium 24 Hour Once Daily Dosing provides lasting relief for frequent heartburn & acid reflux.

Boxed Contents: 14 Mini Capsules Size: 14 Mini Capsules

Warnings

Do not use:

  • For children under 18 years of age.
  • If allergic to esomeprazole.
  • If allergic to any other proton pump inhibitor (omeprazole, rabeprazole, lansoprazole, pantoprazole).
  • If you are taking antiretroviral medicines, such as atazanavir.
  • If you are taking cilostazol, a medicine used to treat pain and/or cramping in the lower leg (or arms) due to inadequate blood flow to the muscles.
  • If you are breastfeeding or intend to breastfeed.
  • If the expiry date printed on the pack has passed.
  • Do not use if foil seal is broken.

CAUTION Always read the label. Follow the directions for use.

Ingredients

Each capsule contains Esomeprazole magnesium trihydrate 22.3mg (equivalent to esomeprazole 20mg)

Active Ingredients: Each capsule contains Esomeprazole magnesium trihydrate 22.3mg (equivalent to esomeprazole 20mg)

Directions

Adults 18 years, of age and over: Take 1 capsule daily for at least 7 days and up to 14 days.

Swallow the capsule whole with water, with or without food. Do not crush, chew or open the capsule. Not intended for immediate relief. It may take a few days to achieve maximum results.

Do not take for more than 14 days unless directed by a doctor.

USAGE ADVICE The bottle contains a sealed container with silica gel desiccant. Keep the bottle tightly closed to protect from moisture.

SAFETY DIRECTIONS

Carefully read the enclosed leaflet before use.

Ask your doctor or pharmacist before use if you:

  • Are pregnant or intend to become pregnant,
  • Have or ever have had serious liver disease.
  • Are taking digoxin (a medicine used to treat heart problems.
  • Are taking ketoconazole (a medicine used to treat fungal infections).
  • Are taking clopidogrel or warfarin (medicines used to stop the blood clotting).
  • Are taking other medicines regularly.

STORAGE INSTRUCTIONS Store below 25°C in a cool, dry place. Storage Temperature: Below 25°C.

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  • Store in a cool, dry place.
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Always consult your healthcare provider to ensure safety and contents. Incorrect use could be harmful.

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Description

Nexium 24HR Once Daily Dosing Tablets provide lasting relief from frequent heartburn and acid reflux

Nexium 24HR Once Daily Dosing Tablets provide lasting relief from frequent heartburn and acid reflux. Nexium 24HR 20mg esomeprazole tablets are for the lasting symptomatic relief of frequent heartburn, acid regurgitation and other symptoms associated with gastro-oesophageal reflux

Carefully read the enclosed Consumer Medicine Information before use.

AUST R NUMBER:

231439

Ingredients

CONTAINS:

Lactose

INGREDIENTS:

Each tablet contains: Esomeprazole 20mg (as Magnesium Trihydrate).

Instructions

DOSAGE:

Nexium is taken once daily as needed. Daily dosage is 2 tablets to be taken once daily. Take this medicine at approximately the same time each day with food.

Space it on the person’s lips, even if symptoms take you an hour or so before they appear. Don’t suddenly stop using Nexium without first talking to your doctor. Do not use certain Nexium tablets for other reasons. Ask your doctor if your symptoms are new or if you still have symptoms of acid reflux.

POSSIBLE SIDE EFFECTS:

Mention any drug that you are using, whether that is esomeprazole, omeprazole, pantoprazole or any other similar proton pump inhibitor. If you have been prescribed one of the other medicines listed here for the treatment of acid reflux, mention it in your prescription.

Lab Test results

SAFETY RESULTS:

Keep all medical history, and any other questions you have been asked.

Do not use:

during the last 3 months of pregnancy.

Lifestyle changes

These may take some time to start working. You may need to take these for a few days after you stop using Nexium.These medicines cannot be used with other proton pump inhibitors (PPIs) such as omeprazole or pantoprazole.These medicines may cause side effects, although not major side effects. Consult your doctor or pharmacist before using any new medicine.To reduce your risk of side effects, you should not exceed the recommended dose. If you have questions about why this medicine has been prescribed for you, talk to your doctor or pharmacist.If you have not used your medicine before, or if there is a quick reference, consult your doctor or pharmacist.If you are allergic to esomeprazole, omeprazole or pantoprazole, you are unlikely to get any other side effects. Consult your doctor if you experience any symptoms of an allergic reaction such as: a skin rash, itchy, hives, itching, difficulty breathing, swelling of the face, lips, tongue or throat, or swelling of any part of the body.These medicines may interfere with each other’s in the production of new cells, and may cause problems in the eye. You may need to stop taking these medicines suddenly.These medicines may cause side effects such as: stomach upset, nausea, vomiting, loss of appetite, constipation, dry mouth, dizziness, blurred vision, or an increase in blood pressure. Stop using this medicine and contact your doctor immediately if you experience severe side effects. Many people experience loss of appetite and weight gain.These medicines may cause side effects such as: diarrhea, constipation, dizziness, headache, dizziness, rash, stomach upset, or dizziness.This medicine does not protect you or your doctor from other drugs with which you are not familiar. You may have questions about drugs to avoid while using this medicine.If you have any questions about the Consumer Medicine Information, ask your doctor or pharmacist if you are still using any other medicines or treatments you have ever used before.